Toluene, o,alpha-dichloro-
2-Chlorobenzyl chloride
CAS: 611-19-8
Molecular Formula: C7H6Cl2
Toluene, o,alpha-dichloro- - Names and Identifiers
| Name | 2-Chlorobenzyl chloride |
| Synonyms | ,2-Dichlorotoluene 2-Chlorobenzyl chloride O-CHLOROBENZYL CHLORIDE o,alpha-dichlorotoluene alpha,o-dichloro-toluen Toluene, o,alpha-dichloro- Ortho-alpha-dichlorotoluene 1-chloro-2-(chloromethyl)-benzen Benzene,1-chloro-2-(chloromethyl)- |
| CAS | 611-19-8 |
| EINECS | 210-258-8 |
| InChI | InChI=1/C7H6Cl2/c8-5-6-3-1-2-4-7(6)9/h1-4H,5H2 |
Toluene, o,alpha-dichloro- - Physico-chemical Properties
| Molecular Formula | C7H6Cl2 |
| Molar Mass | 161.029 |
| Density | 1.247g/cm3 |
| Melting Point | -13℃ |
| Boling Point | 213.7°C at 760 mmHg |
| Flash Point | 82.2°C |
| Water Solubility | insoluble |
| Vapor Presure | 0.236mmHg at 25°C |
| Refractive Index | 1.546 |
| Physical and Chemical Properties | Melting Point -17 ℃ Boiling Point 213-214 ℃ relative density 1.2699 refractive index 1.5895 |
| Use | It is a synthetic pyrethroid insecticide, which has the effect of killing and stomach poison, broad insecticidal spectrum, rapid knockdown and long durationFor the control of Pear Tree pear wood lice and other pestsIt has a good killing effect on a variety of lepidopteran larvae, can also effectively control some underground pests, and has a repellent effect on some adults |
Toluene, o,alpha-dichloro- - Risk and Safety
| Hazard Symbols | C - Corrosive N - Dangerous for the environment  |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R34 - Causes burns R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S29 - Do not empty into drains. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2235 |
Toluene, o,alpha-dichloro- - Upstream Downstream Industry
| Raw Materials | Phosphorus trichloride o-Toluidine 2,2'-Azobis(2-methylpropionitrile) 2-Chlorotoluene |
| Downstream Products | 2-Chlorophenylacetic acid Isooxadiazon Econazole |
Toluene, o,alpha-dichloro- - Preparation Method
Open Data Verified Data
with o-toluidine as raw material, by diazotization replacement, chlorination derived. O-toluidine, hydrochloric acid and water were mixed and cooled to 0-5 °c, and sodium nitrite was added dropwise to conduct diazotization reaction. Under rapid stirring, pour cuprous chloride at 0 ℃, naturally raise the temperature to 20~25 ℃, and finally rise to 60~65 ℃, keep the temperature for 20min, then cool, stand, layer, wash and distill, O-chlorotoluene was obtained. O-chlorotoluene is mixed with phosphorus trichloride, and the chlorine is passed at 130~140 ℃ to obtain O-chlorobenzyl chloride.
Last Update：2022-01-01 10:41:08
Toluene, o,alpha-dichloro- - Safety
Open Data Verified Data
- vapor has strong irritation and tear resistance, mouse LD50 467mg/kg. The workshop should be well ventilated, the equipment should be sealed, and the operator should wear protective equipment.
- treated as a corrosive liquid in transport. Packaged in glass bottles, nickel barrels and lined steel barrels. It can also be packed in lead-lined tanks, nickel tanks or ceramic tanks.
Last Update：2022-01-01 10:41:09
Toluene, o,alpha-dichloro- - Security information
| WGK Germany | 3 |
| RTECS number | CZ0195000 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| customs code | 29036990 |
Last Update：2024-04-10 22:29:15
Toluene, o,alpha-dichloro- - Nature
| vapor density | 5.5 (vs air) |
| Vapor pressure | 3mm Hg ( 84 °C) |
| refractive index | n20/D 1.559(lit.) |
| flash point | 180 °F |
| storage conditions | 2-8°C |
| morphology | Liquid |
| color | Clear colorless to slightly yellow |
| explosion limit value (explosive limit) | 1.5-7.8%(V) |
| water solubility | insoluble |
| BRN | 471700 |
| InChIKey | BASMANVIUSSIIM-UHFFFAOYSA-N |
| NIST chemical information | Benzene, 1-chloro-2-(chloromethyl)-(611-19-8) |
| EPA chemical information | 2-Chlorobenzyl chloride (611-19-8) |
Last Update：2024-04-09 20:48:19
Toluene, o,alpha-dichloro- - Uses and synthesis methods
chemical properties
this product is colorless liquid, B. p.215 ~ 216 ℃,n20D 1.5550, relative density 1.270,f.p.98 ℃, soluble in benzene, toluene and other organic solvents.
use
1, o-chlorobenzyl chloride is an intermediate of the herbicide isoxapine, and it is also an intermediate of the pharmaceutical enzyme Yining.
2, organic synthetic raw materials, used in the pharmaceutical industry to make excitatory drugs, enzyme inhibition, etc.
3. Used in the production of o-chlorobenzyl, o-chlorobenzyl alcohol, synthetic dyes, pharmaceuticals, etc.
4. It is a synthetic pyrethroid insecticide. It has the effects of contact and stomach toxicity. It has a wide insecticidal spectrum, quick knockdown, and a long lasting period. It is used to prevent and control pests such as pear tree, pear and woodlice. It has a good killing effect on a variety of lepidopteran larvae. It can also effectively control certain underground pests and has a rejection effect on certain adults
production method
1. it is obtained by diazotization replacement and chlorination with o-toluidine as raw material. Mix o-toluidine, hydrochloric acid and water, cool to 0-5 ℃, drop sodium nitrite, and carry out diazotization reaction. Under rapid stirring, pour cuprous chloride at 0 ℃, naturally raise the temperature to 20-25 ℃, finally rise to 60-65 ℃, keep the temperature for 20min, then cool, stand, layer, wash and distill to obtain o-chlorotoluene. O-chlorotoluene is mixed with phosphorus trichloride and chlorinated at 130-140 ℃ to obtain o-chlorobenzyl chloride.
2. the preparation method is to mix o-chlorotoluene and phosphorus trichloride in a reactor, introduce chlorine gas at 130~140 ℃ until the relative density of the reaction liquid reaches 1.20~1.22, and then fractionate to obtain the product.
It is also possible to use azobisisobutyronitrile as a catalyst to chlorinate o-chlorotoluene in a solvent to produce a product.
category
Toxic substances
toxicity classification
Poisoning
acute toxicity
Inhalation-rat LC50: > 1140 mg/m3/1 hour; Not reported-rat LD50: 430 mg/kg
flammability hazard characteristics
Thermal decomposition discharges toxic chloride fumes
storage and transportation features
Warehouse low temperature ventilation and drying
fire extinguishing agent
Carbon dioxide, foam, dry powder
Last Update：2024-04-09 19:04:55
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Raw Materials for Toluene, o,alpha-dichloro-
Downstream Products for Toluene, o,alpha-dichloro-